Results showed that the combined treatment suppressed the growth and metastasis of the cancer cells . Establishment of porcine and human expanded potential stem cells.
PEX-producing human neural stem cells inhibit tumor growth in a mouse glioma model. The three systems have been used to modify MSCs, and showed efficacy in treatment of brain, breast, ovarian and prostate cancers in mouse models .Duraiswamy J. This finding can lead to developing ways to protect hESCs from allogenic immune rejection without the need for systemic immune suppression . Three main suicide gene systems are utilized: 1 Conversion of 5-fluorocytosine 5-FC to the toxic anti-metabolite 5-fluorouracil 5-FU via cytosine deaminase CD enzyme, 2 Conversion of the inactive Irinotecan drug to the topoisomerase inhibitor SN by carboxylesterase enzyme, 3 Conversion of the Ganciclovir GCV drug to its phosphorylated forms to block DNA synthesis through the action of the thymidine kinase enzyme. Challenges facing stem cell therapy Although stem cells hold great promise in therapeutics, it is necessary to provide scientific evidence on the safety and effectiveness of their usage . Stem cells role in post-cancer treatment In hematological cancers, bone marrow transplantation is a conventional protocol used to restore the cellular components of the blood after chemotherapy rounds. Personalised medicine: genome maintenance lessons learned from studies in yeast as a model organism, ; Komarova S. Moreover, 18 patients with high-grade glioma were enrolled in a clinical trial that has started in and is expected to be complete by Human stem cells expressing novel TSP-1 variant have anti-angiogenic effect on brain tumors.
Graft-versus-host disease: a complex long-term side effect of hematopoietic stem cell transplant. That is the reasons why clinical trials using iPSCs are scarce.
For example, human MSCs were modified to secrete IL and IL, shifting the immune response against cervical cancer, renal cell carcinoma and glioblastoma in mice through the activation of natural killer cells and tumor-specific T cells .
Abugable AA, et al. Challenges facing stem cell therapy Although stem cells hold great promise in therapeutics, it is necessary to provide scientific evidence on the safety and effectiveness of their usage .
Moreover, a recent clinical study showed that combining T-VEC oncolytic virotherapy with immunotherapy increased the infiltration of T cells to the tumor vicinity . Tumor volumes were significantly reduced and the survival rate of mice increased remarkably .
InKikuchi et al.
It was proven that the administration method of the stem cells was safe, practicable and showed no adverse effects; however, it should be further tested for its clinical effectiveness on AD pathogenesis.